Gifford A N, Wang R Y
Department of Psychiatry and Behavioral Sciences, State University of New York at Stony Brook 11794-8790.
Brain Res. 1994 Feb 28;638(1-2):325-8. doi: 10.1016/0006-8993(94)90665-3.
In extracellular recordings from chloral hydrate anesthetized rats the 5-HT3 antagonist, BRL 46470A, failed to prevent or reverse the increase in dopamine cell firing rate produced by systemic or iontophoretically applied morphine. A second 5-HT3 antagonist, tropesitron, was similarly found to be ineffective in antagonizing the effects of systemic morphine. These results suggest that previous microdialysis reports that 5-HT3 antagonists can prevent the increase in extracellular dopamine levels in the nucleus accumbens produced by morphine are not due to an action of these compounds in suppressing the excitatory effects of morphine on A10 dopamine cell firing rate.
在对水合氯醛麻醉的大鼠进行的细胞外记录中，5-羟色胺3（5-HT3）拮抗剂BRL 46470A未能预防或逆转全身给药或离子导入法给予吗啡所引起的多巴胺能细胞放电率增加。同样发现，另一种5-HT3拮抗剂托烷司琼在拮抗全身给予吗啡的作用方面无效。这些结果表明，先前的微透析报告称5-HT3拮抗剂可预防吗啡引起的伏隔核细胞外多巴胺水平升高，并非是由于这些化合物抑制了吗啡对A10多巴胺能细胞放电率的兴奋作用。
