Jacobsen B B, Andersen H, Dige-Petersen H, Hummer L
Acta Paediatr Scand. 1976 Jul;65(4):433-8. doi: 10.1111/j.1651-2227.1976.tb04911.x.
The serum concentration of thyrotropin (TSH) and the TSH response following thyrotropin-releasing hormone (TRH) were studied in 16 euthyroid babies from 16 to 172 hours after birth and in 2 primary hypothyroid babies, 3 and 28 days of age. Serum-TSH was measured before an intravenous injection of 40 mug TRH and after 30 and 180 min. In the euthyroid babies increased basal levels of TSH were seen shortly after birth, followed by a pronounced decline. The extent of TSH increase after TRH could be correlated with the basal levels, and the relative increase was comparable to that which occurs in adults. In the hypothyroid babies very high basal levels of serum-TSH were seen, 125 and 400 muU/ml respectively, with no further increase following TRH stimulation. It was concluded that in euthyroid fullterm newborn, the relative response of serum-TSH to TRH was equal to that of adults, in spite of elevated thyroid hormone concentrations. In the hypothyroid newborn very high levels of serum-TSH were seen and a supplementary TRH-test seems without diagnostic value in congenital hypothyroidism.
对16例出生后16至172小时的甲状腺功能正常的婴儿以及2例分别为3日龄和28日龄的原发性甲状腺功能减退婴儿，研究了促甲状腺激素（TSH）的血清浓度以及促甲状腺激素释放激素（TRH）刺激后的TSH反应。在静脉注射40μg TRH前以及注射后30分钟和180分钟测量血清TSH。甲状腺功能正常的婴儿出生后不久TSH基础水平升高，随后显著下降。TRH刺激后TSH升高的程度与基础水平相关，相对升高幅度与成人相当。甲状腺功能减退的婴儿血清TSH基础水平非常高，分别为125和400μU/ml，TRH刺激后无进一步升高。得出的结论是，在甲状腺功能正常的足月新生儿中，尽管甲状腺激素浓度升高，但血清TSH对TRH的相对反应与成人相同。在甲状腺功能减退的新生儿中，血清TSH水平非常高，补充TRH试验在先天性甲状腺功能减退症中似乎没有诊断价值。
