Dow J A, Maddrell S H, Davies S A, Skaer N J, Kaiser K
Department of Cell Biology, University of Glasgow, United Kingdom.
Am J Physiol. 1994 May;266(5 Pt 2):R1716-9. doi: 10.1152/ajpregu.1994.266.5.R1716.
The nitric oxide (NO) signaling pathway plays major roles in the vertebrate vascular, nervous, and immune systems. Here we present evidence that all the elements in the NO pathway are present in, and act to control epithelial fluid secretion by, the Malpighian tubules of an insect, Drosophila melanogaster. This finding will allow both a physiological and a molecular genetic dissection of the NO pathway in the same tissue.
一氧化氮（NO）信号通路在脊椎动物的血管、神经和免疫系统中发挥着主要作用。在此，我们提供证据表明，NO通路中的所有元件都存在于昆虫黑腹果蝇的马氏管中，并对其上皮液体分泌起控制作用。这一发现将使得在同一组织中对NO通路进行生理学和分子遗传学剖析成为可能。
