黏膜分泌免疫在阿米巴病疫苗研发中的作用。
Role of mucosal secretory immunity in the development of an amebiasis vaccine.
作者信息
Ravdin J I, Kelsall B L
机构信息
Department of Medicine, Case Western Reserve University, Cleveland, Ohio.
出版信息
Am J Trop Med Hyg. 1994;50(5 Suppl):36-41.
Invasive colonic infection by the enteric protozoan Entamoeba histolytica elicits a mucosal anti-amebic IgA antibody response. The E. histolytica galactose-inhibitable adherence protein (GIAP) mediates parasite binding to colonic mucins and epithelial cells. Anti-GIAP secretory IgA antibodies are found during invasive amebiasis and can be elicited by immunization of rats with the native protein. Entamoeba histolytica contains potent IgA degradative activities due to its cysteine-specific proteases. Research is needed to further understand the role of secretory antibodies in natural or vaccine-induced immunity to E. histolytica.
肠道原生动物溶组织内阿米巴引起的侵袭性结肠感染会引发黏膜抗阿米巴IgA抗体反应。溶组织内阿米巴半乳糖抑制性黏附蛋白（GIAP）介导寄生虫与结肠黏蛋白和上皮细胞的结合。在侵袭性阿米巴病期间可发现抗GIAP分泌型IgA抗体，用天然蛋白免疫大鼠可引发该抗体。由于其半胱氨酸特异性蛋白酶，溶组织内阿米巴具有强大的IgA降解活性。需要开展研究以进一步了解分泌性抗体在对溶组织内阿米巴的天然免疫或疫苗诱导免疫中的作用。
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