Minei L J, Suzuki K
Obstet Gynecol. 1976 Aug;48(2):177-81.
In order to determine the precise role played by the absence of fetal swallowing or urine contribution in the disposal and production of amniotic fluid, we surgically occluded the fetal esophagus in 5 monkeys and the urethra in 2 monkeys. The amniotic fluid volume was then measured daily with an indicator dilution technic. Sham operations were performed on 3 monkeys of similar gestational age. It was found that in late pregnancy failure of fetal deglutition resulted in transient hydramnios which appeared to be followed by a readjustment in water exchange rates in other pathways by which the amniotic fluid volume returned to normal range. In midpregnancy fetal deglutition seems to have no appreciable effect upon the amniotic fluid volume. Diversion of fetal urine, however, appeared to result in a persistent decrease in the volume of the amniotic fluid.
为了确定胎儿吞咽或尿液分泌缺失在羊水的排出和生成中所起的精确作用，我们对5只猴子进行手术阻断其胎儿食管，对2只猴子阻断其胎儿尿道。然后每天用指示剂稀释技术测量羊水量。对3只孕龄相似的猴子进行假手术。结果发现，在妊娠晚期，胎儿吞咽功能衰竭导致短暂性羊水过多，随后其他羊水交换途径的水交换率似乎重新调整，羊水量恢复到正常范围。在妊娠中期，胎儿吞咽似乎对羊水量没有明显影响。然而，胎儿尿液分流似乎导致羊水量持续减少。
