频繁发作儿童的脑灌注单光子发射计算机断层扫描

Brain perfusion SPECT in children with frequent fits.

作者信息

Heiskala H, Launes J, Pihko H, Nikkinen P, Santavuori P

机构信息

Department of Child Neurology, University Central Hospital, Helsinki, Finland.

出版信息

Brain Dev. 1993 May-Jun;15(3):214-8. doi: 10.1016/0387-7604(93)90067-i.

DOI:10.1016/0387-7604(93)90067-i

PMID:8214347

Abstract

We studied 14 children with frequent fits using 99mTc-HM-PAO single photon emission computed tomography (SPECT). There were 11 patients with partial secondary generalized epilepsy (PSGE) and 3 with Lennox-Gastaut syndrome (LGS). The typical regional cerebral blood flow (rCBF) finding in PSGE was a single area of abnormally low perfused cortex, and that in LGS, multiple hypoperfused areas. Clinically, the LGS patients were more severely affected. SPECT was more sensitive in detecting abnormalities than EEG, CT or MRI. Extensive impairment of rCBF may thus indicate unfavourable development of intellectual performance and poor seizure control.

摘要

我们使用99mTc-HM-PAO单光子发射计算机断层扫描（SPECT）对14例频发癫痫发作的儿童进行了研究。其中11例为部分性继发性全身性癫痫（PSGE）患者，3例为Lennox-Gastaut综合征（LGS）患者。PSGE典型的局部脑血流（rCBF）表现为单个皮质灌注异常减低区，而LGS则为多个灌注减低区。临床上，LGS患者病情更严重。SPECT在检测异常方面比脑电图、CT或MRI更敏感。因此，rCBF的广泛损害可能预示着智力发育不良和癫痫控制不佳。