果蝇中的一个新的肌球蛋白I基因。
A new myosin I gene in Drosophila.
作者信息
Cheney C M, Kravit N G, Verbsky J W
机构信息
Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110.
出版信息
Biochem Biophys Res Commun. 1993 Sep 30;195(3):1280-8. doi: 10.1006/bbrc.1993.2182.
We have identified and cloned a new myosin-I cDNA, myosin 61F, from Drosophila melanogaster. The sequence of myosin 61F cDNA shows high similarity to vertebrate myosin-I sequences. Myosin 61F is most similar to bovine myosin Ib, showing 78% similarity and 63% identity. Myosin 61F is a single copy gene which maps to polytene region 61F, a genomic region with several potential myosin mutations. The identification of a myosin-I gene in Drosophila will allow genetic analysis of myosin-I function in a metazoan organism.
我们从黑腹果蝇中鉴定并克隆了一个新的肌球蛋白-I cDNA，即肌球蛋白61F。肌球蛋白61F cDNA的序列与脊椎动物肌球蛋白-I序列具有高度相似性。肌球蛋白61F与牛肌球蛋白Ib最为相似，相似度为78%，一致性为63%。肌球蛋白61F是一个单拷贝基因，定位于多线染色体区域61F，该基因组区域存在多个潜在的肌球蛋白突变。果蝇中肌球蛋白-I基因的鉴定将有助于对后生动物中肌球蛋白-I功能进行遗传分析。
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