HIV与人类补体：相互作用机制及生物学意义
HIV and human complement: mechanisms of interaction and biological implication.
作者信息
Dierich M P, Ebenbichler C F, Marschang P, Füst G, Thielens N M, Arlaud G J
机构信息
Institut für Hygiene, Leopold Franzens Universität, Innsbruck, Austria.
出版信息
Immunol Today. 1993 Sep;14(9):435-40. doi: 10.1016/0167-5699(93)90246-H.
PMID:8216721
Abstract
Human complement, although not lytic for HIV-1, interacts with the virus and is closely involved in the infectious process. It enhances infection in the absence of antibody, and turns neutralizing antibodies into agents which increase viral infectivity. In this review M.P. Dierich et al. summarize available information and discuss possible biological implications.
摘要
人类补体虽然对HIV-1没有溶解作用，但能与该病毒相互作用，并密切参与感染过程。在没有抗体的情况下，补体可增强感染，并将中和抗体转变为增加病毒感染性的因子。在这篇综述中，M.P. 迪里希等人总结了现有信息并探讨了可能的生物学意义。
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