骨髓中伴有嗜酸性粒细胞增多的骨髓增生异常综合征。群马血液学研究组。

Myelodysplastic syndrome with eosinophilia in bone marrow. Gunma Haematology Study Group.

作者信息

Matsushima T, Murakami H, Sawamura M, Tamura J, Sakura T, Matsumoto M, Hirabayashi H, Miyawaki S, Simano S, Sato S

机构信息

Third Department of Internal Medicine, Gunma University School of Medicine.

出版信息

Br J Haematol. 1993 Aug;84(4):636-8. doi: 10.1111/j.1365-2141.1993.tb03139.x.

DOI:10.1111/j.1365-2141.1993.tb03139.x

PMID:8217821

Abstract

Clinical features were investigated in 114 patients with de novo myelodysplastic syndrome (MDS) diagnosed over the past 10 years, and eight cases (7%) were complicated with eosinophilia in the bone marrow. Two patients had refractory anaemia (RA), five had RA with excess of blasts (RAEB), and one had RAEB in transformation. Their bone marrow cells exhibited tri-lineage dysplasia and morphological abnormalities in eosinophils. Cytogenetics revealed major karyotype abnormalities (MAKA) in five patients. Survival durations were significantly shorter than those of other MDS patients. Our study suggests that marrow eosinophilia in MDS is strongly related to the coexistence of MAKA.

摘要

对过去10年中诊断出的114例初发骨髓增生异常综合征（MDS）患者的临床特征进行了调查，其中8例（7%）骨髓伴有嗜酸性粒细胞增多。2例为难治性贫血（RA），5例为伴有过多原始细胞的RA（RAEB），1例为转化中的RAEB。他们的骨髓细胞表现出三系发育异常以及嗜酸性粒细胞的形态异常。细胞遗传学显示5例患者存在主要核型异常（MAKA）。生存时间明显短于其他MDS患者。我们的研究表明，MDS中的骨髓嗜酸性粒细胞增多与MAKA的共存密切相关。