Santiago E, Mendoza J F, Corona T M, Lopez R, Sanchez L, Mora L M, Flores F, Valencia E, Weiss-Steider B
Laboratory of Cellular Differentiation and Cancer, ENEP-Zaragoza, National University of Mexico, Mexico City.
Eur Cytokine Netw. 1993 May-Jun;4(3):223-8.
Recombinant human interleukin-1 beta (rhIL-1 beta) is shown to be a strong inducer of Fc receptors (FcR) on murine macrophages and not on granulocytes. Data is provided indicating that rhIL-1 beta does induce specific but not nonspecific phagocytosis. Macrophages are shown to autoinduce their FcR expression as a function of time in culture. This induction is increased by the use of exogenous rhIL-1 beta and inhibited by anti-rhIL-1 beta antibody, pointing to an autocrine regulation of FcR expression on macrophages. On the other hand the myelomonocytic cell line WEH13BD- and the macrophage like cell line WR19M.1 are also shown to be inducible for the expression of FcR by this molecule. Data is also provided showing that recombinant murine Interferon gamma (rmIFN gamma) induces FcR on both macrophages and granulocytes. Whereas polyclonal antibodies inhibit FcR induction by IL-1 on macrophages, it does not inhibit FcR induction by IFN gamma on these cells. This points to a different mechanism of induction of FcR by IFN and IL-1. Finally, the possible application of rhIL-1 beta in vivo to help the organism fight infections is discussed.
重组人白细胞介素-1β（rhIL-1β）被证明是小鼠巨噬细胞而非粒细胞上Fc受体（FcR）的强诱导剂。提供的数据表明rhIL-1β确实诱导特异性而非非特异性吞噬作用。巨噬细胞在培养过程中会随着时间自动诱导其FcR表达。使用外源性rhIL-1β可增强这种诱导作用，而抗rhIL-1β抗体则可抑制该作用，这表明巨噬细胞上FcR表达存在自分泌调节。另一方面，髓单核细胞系WEH13BD-和巨噬细胞样细胞系WR19M.1也显示可被该分子诱导表达FcR。还提供了数据表明重组鼠干扰素γ（rmIFNγ）可在巨噬细胞和粒细胞上诱导FcR。虽然多克隆抗体抑制IL-1对巨噬细胞上FcR的诱导，但它并不抑制IFNγ对这些细胞上FcR的诱导。这表明IFN和IL-1诱导FcR的机制不同。最后，讨论了rhIL-1β在体内帮助机体对抗感染的可能应用。
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