Crewther S G, Crewther D P
School of Optometry, University of N.S.W., Kensington, Australia.
Neuroreport. 1993 Sep;4(9):1083-6.
The neural mechanism of strabismic amblyopia was investigated by recording the spatio-temporal properties of striate cortical neurones of cats raised with a surgically induced esotropia. Multiple pseudo-random flashed or phase-alternating stimuli were used, and through cross-correlation, the Wiener kernels were extracted. This analysis has shown that in neurones which retain binocularity to adulthood, two different neural mechanisms of adaptation to ocular misalignment exist. Some of these neurones become amblyopic, such that the non-deviating eye dominates the response for high spatial frequencies while the strabismic eye dominates at low spatial frequencies. Other neurones adapt through active suppression of the monocular response to stimulation of the strabismic eye when the non-deviating eye is simultaneously stimulated.
通过记录因手术诱发内斜视而长大的猫的纹状皮质神经元的时空特性，对斜视性弱视的神经机制进行了研究。使用了多个伪随机闪烁或相位交替刺激，并通过互相关分析提取了维纳核。该分析表明，在成年后仍保持双眼性的神经元中，存在两种不同的适应眼位不正的神经机制。其中一些神经元会变成弱视，即非斜视眼在高空间频率时主导反应，而斜视眼在低空间频率时主导反应。当非斜视眼同时受到刺激时，其他神经元通过主动抑制对斜视眼刺激的单眼反应来进行适应。
