Gembicki M, Dzieciuchowicz S, Sowiński J, Makowska K, Klincewicz H
Pol Med Sci Hist Bull (1973). 1976 Apr-Jun;15(2):213-6.
In 11 patients with compensated and 10 with decompensated liver cirrhosis the following determinations were carried out: total thyroxine serum concentration (T4), triiodothyronine-binding coefficient (T3BC), free thyroxine by the dialysis method (DFT4), free thyroxine index (FT4I) and absolute value of free thyroxine (ADFT4). A statistically significant rise of T3BC, DFT4, ADFT4 and FT4I was observed only in the group of decompensated cirrhosis. It is supposed that these changes develop not as a result of excessive production of thyroid hormones but due to disturbances in the binding capacity of the proteins which bind thyroid hormones and also due to an impaired degradation of these hormones in the liver.
对11例代偿期肝硬化患者和10例失代偿期肝硬化患者进行了以下测定：血清总甲状腺素浓度（T4）、三碘甲状腺原氨酸结合系数（T3BC）、透析法测定的游离甲状腺素（DFT4）、游离甲状腺素指数（FT4I）和游离甲状腺素绝对值（ADFT4）。仅在失代偿期肝硬化组中观察到T3BC、DFT4、ADFT4和FT4I有统计学意义的升高。据推测，这些变化并非由于甲状腺激素分泌过多所致，而是由于结合甲状腺激素的蛋白质结合能力紊乱，以及肝脏中这些激素降解受损所致。
