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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Terada T, Niwase N, Koyama I, Imamura M, Shinagawa K, Toya H, Mizoguchi T

Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, Japan.

Int J Biochem. 1993 Sep;25(9):1233-9. doi: 10.1016/0020-711x(93)90072-m.

Carbonyl reductase, which is distributed in both cytosolic and microsomal fractions in bovine liver, were purified to homogeneity on 12.5% sodium dodecylsulfate-polyacrylamide gel electrophoresis and shown to have molecular weights of 32 kDa and 68 kDa, respectively. 2. Both carbonyl reductases can catalyze the reduction of many carbonyl compounds including ketone, quinones and aldehyde with relatively low Km values. 3. From the absorption spectrum result, microsomal carbonyl reductase closely resembles cytochrome P-450 reductase. 4. Cytosolic carbonyl reductase is a novel enzyme which can act on both testosterone and androsterone at low concentration.

Terada T, Niwase N, Koyama I, Imamura M, Shinagawa K, Toya H, Mizoguchi T

Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, Japan.

Int J Biochem. 1993 Sep;25(9):1233-9. doi: 10.1016/0020-711x(93)90072-m.

Carbonyl reductase, which is distributed in both cytosolic and microsomal fractions in bovine liver, were purified to homogeneity on 12.5% sodium dodecylsulfate-polyacrylamide gel electrophoresis and shown to have molecular weights of 32 kDa and 68 kDa, respectively. 2. Both carbonyl reductases can catalyze the reduction of many carbonyl compounds including ketone, quinones and aldehyde with relatively low Km values. 3. From the absorption spectrum result, microsomal carbonyl reductase closely resembles cytochrome P-450 reductase. 4. Cytosolic carbonyl reductase is a novel enzyme which can act on both testosterone and androsterone at low concentration.