Deletion analysis of Duchenne muscular dystrophy.
作者信息
Erdem H, Ayter S, Ozgüç M, Topçu M, Topaloğlu H, Renda Y
机构信息
Department of Medical Biology, Hacettepe University Faculty of Medicine, Ankara.
出版信息
Turk J Pediatr. 1993 Jan-Mar;35(1):15-21.
PMID:8236513
Abstract
DNA of 15 patients with Duchenne muscular dystrophy (DMD) were analyzed for deletions within the DMD gene by using recombinant DNA technology. Deletion frequency was 47 percent and six of the deletions occurred in the region of probe 7 + 8. Only one of the deletions was observed in the region of probe 9-7, and no deletions were found in the region of probe 30-1, 30-2 and 47-4 (5b + 6). The frequency of deletions found in the Turkish DMD patients corresponds to frequencies reported for other populations.
摘要
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