[The relation between the levels of serum lipid peroxide, superoxide dismutase and atrial natriuretic peptide in placenta, umbilical cord vein and intrauterine growth retardation in pregnancy induced hypertension].

This paper was written on the following base: 31 women with severe pregnancy induced hypertension (PIH) were chosen randomly as an observation group, 32 healthy and gestational age matched pregnant women with uneventful delivery were served as control group. Blood samples were collected from intervillous space of placenta and umbilical cord vein after delivery. The levels of LPO, SOD and atrial natriuretic peptide (ANP) were measured separately. From the placenta point of view, the pathogenic mechanism of PIH and the relation to the occurrence of intrauterine growth retardation (IUGR) were discussed. The results showed: the concentrations of LPO, SOD and ANP of placenta and umbilical cord vein were higher in the PIH group than that in the control group. The difference between 2 groups was statistically significant. A positive correlation between LPO and ANP was found both in PIH group and in control group (r = 0.641, P < 0.02). The birth weight of newborn was 2,174 +/- 142 g in PIH group and 3,460 +/- 187 g in control group. The difference between them was significant (P < 0.01). It suggested that the pathogenesis of PIH and the occurrence of IUGR might be closely related to the high concentration of LPO in placenta and umbilical cord vein.