大鼠背根神经节中谷氨酰胺酶免疫反应性神经元含有降钙素基因相关肽（CGRP）。
Glutaminase immunoreactive neurons in the rat dorsal root ganglion contain calcitonin gene-related peptide (CGRP).
作者信息
Miller K E, Douglas V D, Kaneko T
机构信息
Department of Anatomical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City 73190.
出版信息
Neurosci Lett. 1993 Sep 17;160(1):113-6. doi: 10.1016/0304-3940(93)90926-c.
The co-localization of glutaminase and calcitonin gene-related peptide (CGRP) was examined with immunohistochemistry in the rat dorsal root ganglion (DRG). The majority of the DRG neurons were immunoreactive for glutaminase and all DRG neurons that contained CGRP also contained glutaminase. These results indicate that some DRG neurons release glutamate and CGRP from the same axon terminals in the spinal cord. Co-release of glutamate and CGRP from primary afferents may have multiple effects including fast and slow neurotransmission of sensory information in the spinal cord.
采用免疫组织化学方法检测了大鼠背根神经节（DRG）中谷氨酰胺酶与降钙素基因相关肽（CGRP）的共定位情况。大多数DRG神经元对谷氨酰胺酶呈免疫反应性，并且所有含有CGRP的DRG神经元也都含有谷氨酰胺酶。这些结果表明，一些DRG神经元在脊髓中从相同的轴突终末释放谷氨酸和CGRP。初级传入神经纤维共同释放谷氨酸和CGRP可能具有多种作用，包括脊髓中感觉信息的快速和慢速神经传递。
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