用亚单位呼吸道合胞病毒疫苗对小鼠进行黏膜免疫。
Mucosal immunization with a subunit respiratory syncytial virus vaccine in mice.
作者信息
Walsh E E
机构信息
Department of Medicine, Rochester General Hospital, NY.
出版信息
Vaccine. 1993;11(11):1135-8. doi: 10.1016/0264-410x(93)90075-9.
PMID:8249433
Abstract
The protective efficacy of mucosal immunization with purified respiratory syncytial virus (RSV) fusion protein (F) using cholera toxin (CT) as an adjuvant was assessed in mice. Intranasal vaccination with F+CT induced F-specific serum IgG and nasal IgA and resulted in 75% protection from nasal virus replication compared with control mice. Intranasal CT+F with simultaneous parenteral F provided complete protection equivalent to intranasal live virus immunization.
摘要
在小鼠中评估了以霍乱毒素（CT）为佐剂，用纯化的呼吸道合胞病毒（RSV）融合蛋白（F）进行黏膜免疫的保护效果。用F+CT进行鼻内接种诱导产生了F特异性血清IgG和鼻内IgA，与对照小鼠相比，可使75%的小鼠免受鼻内病毒复制的影响。鼻内CT+F同时联合胃肠外给予F可提供与鼻内活病毒免疫相当的完全保护。
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