丙戊酸盐治疗引起的红细胞变化。

Changes in red blood cells with valproate therapy.

作者信息

Ozkara C, Dreifuss F E, Apperson Hansen C

机构信息

Comprehensive Epilepsy Program, University of Virginia, Charlottesville 22908.

出版信息

Acta Neurol Scand. 1993 Sep;88(3):210-2. doi: 10.1111/j.1600-0404.1993.tb04218.x.

DOI:10.1111/j.1600-0404.1993.tb04218.x

PMID:8256557

Abstract

Increase in the red blood cell mean corpuscular volume (MCV), and mean corpuscular haemoglobin (MCH) values in patients receiving Valproate as mono or polytherapy was noted. To investigate this situation 41 epileptic patients were studied on Valproate alone (Group 1) and 20 patients on Valproate added to another antiepileptic drug (AED), (Group 4), and compared with 19 patients on carbamazepine (CBZ) (Group 2) and 12 patients on phenytoin (PHT), (Group 3). The results showed significant rise in MCV values in Groups 1 and 4. The peripheral blood smear and other tests including reticulocyte counts of the patients with abnormal values ruled out macrocytic anemias. We postulate a generalized effect which is the result of alteration in erythrocyte membrane phospholipids.

摘要

接受丙戊酸盐单一疗法或联合疗法的患者，其红细胞平均体积（MCV）和平均红细胞血红蛋白含量（MCH）值有所升高。为研究此情况，对41例仅接受丙戊酸盐治疗的癫痫患者（第1组）和20例在使用另一种抗癫痫药物（AED）基础上加用丙戊酸盐的患者（第4组）进行了研究，并与19例接受卡马西平（CBZ）治疗的患者（第2组）和12例接受苯妥英（PHT）治疗的患者（第3组）进行比较。结果显示，第1组和第4组的MCV值显著升高。对MCV值异常患者的外周血涂片及包括网织红细胞计数在内的其他检查排除了巨幼细胞贫血。我们推测这是一种全身性效应，是红细胞膜磷脂改变的结果。