多发性肌炎/皮肌炎患者的可溶性CD4、CD8

Soluble CD4, CD8 in patients with polymyositis/dermatomyositis.

作者信息

Tokano Y, Obara T, Hashimoto H, Okumura K, Hirose S

机构信息

Department of Internal Medicine, Juntendo University, School of Medicine, Tokyo, Japan.

出版信息

Clin Rheumatol. 1993 Sep;12(3):368-74. doi: 10.1007/BF02231582.

DOI:10.1007/BF02231582

PMID:8258239

Abstract

The concentrations of soluble CD4 (sCD4) and soluble CD8 (sCD8) were determined in 64 patients with polymyositis/dermatomyositis (PM/MD). The patients with PM/DM had significantly higher concentrations of sCD8, though the concentrations of sCD4 did not significantly increase. Patients with high concentrations of sCD8 tended to have too high concentrations of soluble interleukin-2 receptor (sIL-2R). The patients with high levels of myogenic enzymes tended to have high concentrations of sCD8. The results of a serial study indicated that the concentrations of sCD8 decreased simultaneously with the decrease of the myogenic enzymes. These results may suggest that the activation of CD8+ cells are related to muscular involvement.

摘要

测定了64例多发性肌炎/皮肌炎（PM/DM）患者可溶性CD4（sCD4）和可溶性CD8（sCD8）的浓度。PM/DM患者的sCD8浓度显著更高，尽管sCD4浓度没有显著升高。sCD8浓度高的患者往往可溶性白细胞介素-2受体（sIL-2R）浓度也过高。肌源性酶水平高的患者往往sCD8浓度也高。一项系列研究结果表明，sCD8浓度随着肌源性酶的降低而同时下降。这些结果可能提示CD8+细胞的激活与肌肉受累有关。