晚期胸腺切除对免疫接种绵羊红细胞的大鼠体内可的松和睾酮免疫抑制作用的影响。

The effects of late thymectomy on the immunosuppressive action of cortisone and testosterone in rats immunized to sheep red blood cells.

作者信息

Aschkenasy A

出版信息

Acta Haematol. 1976;56(4):212-20. doi: 10.1159/000207940.

DOI:10.1159/000207940

Abstract

The immunological effects of cortisone and testosterone were studied in intact and lately thymectomized rats immunized to sheep red cells. The results showed that the effects of low doses of cortisone as well as those of high doses of testosterone (drop in the total number of rosette- and plaque-forming cells: RFC and PFC) were conditioned by the involution of the thymic cortex provoked by such hormonal doses, since these changes did not occur in thymectomized rats. The effects of high doses of cortisone were partly not influenced by thymectomy (drop in the RFC and PFC levels) but partly thymus-dependent (drop in the serum antibody titers). The latter were apparently related to advanced lesions of the thymic medulla.

摘要

对用绵羊红细胞免疫的正常大鼠和近期切除胸腺的大鼠，研究了可的松和睾酮的免疫效应。结果表明，低剂量可的松以及高剂量睾酮的效应（玫瑰花结形成细胞和空斑形成细胞总数：RFC和PFC下降）受此类激素剂量引起的胸腺皮质退化的制约，因为这些变化在切除胸腺的大鼠中未出现。高剂量可的松的效应部分不受胸腺切除的影响（RFC和PFC水平下降），但部分依赖胸腺（血清抗体滴度下降）。后者显然与胸腺髓质的晚期病变有关。