Bickle Q, Anders R F, Day K, Coppel R L
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Mol Biochem Parasitol. 1993 Oct;61(2):189-96. doi: 10.1016/0166-6851(93)90065-6.
S-antigens are heat-stable, highly polymorphic proteins released by Plasmodium falciparum at the time of schizont rupture. Previously determined S-antigen sequences allowed the proposal of a general gene structure consisting of 5 sequence blocks. The sequence of the central block of tandem repeats provides a useful means of distinguishing the S-antigen allele and also its serotype, whereas the amino and carboxy terminal sequences defined the S-antigen family, 4 of which have been described. We present the sequence of 3 new S-antigen alleles, for the isolates HB3, KF1916 and KF1917. The allele-defining repeat sequence is ETGPGKAGEQG for HB3, GDQTEGS(S/A)GGK for KF1917 and AGSNE(E/K) for KF1916. The sequences of these newly described S-antigens are consistent with the proposed general gene structure and all belong to defined families, although carboxy-terminal sequences appear to be much more variable within a family than previously realised.
S抗原是恶性疟原虫在裂殖体破裂时释放的热稳定、高度多态性的蛋白质。先前确定的S抗原序列使得人们提出了一种由5个序列块组成的一般基因结构。串联重复中央块的序列提供了一种区分S抗原等位基因及其血清型的有用方法，而氨基和羧基末端序列定义了S抗原家族，其中已经描述了4个家族。我们展示了分离株HB3、KF1916和KF1917的3个新S抗原等位基因的序列。定义HB3等位基因的重复序列是ETGPGKAGEQG，KF1917是GDQTEGS(S/A)GGK，KF1916是AGSNE(E/K)。这些新描述的S抗原的序列与提出的一般基因结构一致，并且都属于已定义的家族，尽管羧基末端序列在一个家族内的变异性似乎比之前意识到的要大得多。
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