Jones J W, Davis A T
Department of Pharmacy, Butterworth Hospital, Grand Rapids, MI 49503.
Am J Hosp Pharm. 1993 Nov;50(11):2364-5.
The stability of bupivacaine hydrochloride injection 1.25 mg/mL in 0.9% sodium chloride injection in polypropylene syringes was studied. Plastic syringes containing bupivacaine hydrochloride 1.25 mg/mL in 0.9% sodium chloride injection or 0.9% sodium chloride injection alone were stored at 3 or 25 degrees C. A glass vial containing the admixture was stored at 25 degrees C as a control. For each condition, triplicate samples were observed immediately and 5, 11, 15, and 32 days after preparation for precipitation and color change and analyzed for pH and for drug concentration by high-performance liquid chromatography. No change in bupivacaine concentration was observed during the 32-day study period, nor was there any change in color or pH nor any development of precipitation. Bupivacaine hydrochloride 1.25 mg/mL in 0.9% sodium chloride injection in polypropylene syringes was stable for up to 32 days when stored at 3 or 23 degrees C.
研究了1.25mg/mL盐酸布比卡因注射液在聚丙烯注射器中与0.9%氯化钠注射液混合后的稳定性。含有1.25mg/mL盐酸布比卡因的0.9%氯化钠注射液或单独的0.9%氯化钠注射液的塑料注射器在3或25℃下储存。一个装有混合液的玻璃瓶在25℃下储存作为对照。对于每种情况，在制备后立即以及5、11、15和32天后观察三份重复样品的沉淀和颜色变化，并通过高效液相色谱法分析pH值和药物浓度。在32天的研究期间未观察到布比卡因浓度的变化，颜色、pH值也没有任何变化，也没有出现沉淀。1.25mg/mL盐酸布比卡因在聚丙烯注射器中与0.9%氯化钠注射液混合后，在3或23℃下储存长达32天是稳定的。
