氯氮平及其主要代谢物的血清浓度：与氟西汀或丙戊酸盐联合治疗的效果。

Serum concentrations of clozapine and its major metabolites: effects of cotreatment with fluoxetine or valproate.

作者信息

Centorrino F, Baldessarini R J, Kando J, Frankenburg F R, Volpicelli S A, Puopolo P R, Flood J G

机构信息

Department of Psychiatry, Harvard Medical School, Boston, MA.

出版信息

Am J Psychiatry. 1994 Jan;151(1):123-5. doi: 10.1176/ajp.151.1.123.

DOI:10.1176/ajp.151.1.123

PMID:8267110

Abstract

Serum concentrations of clozapine, norclozapine, and clozapine-N-oxide were assayed in psychotic patients treated with clozapine alone (N = 17), clozapine with fluoxetine added (N = 6), or clozapine with valproic acid added (N = 11). Subjects were matched for age and other treatments, and concentrations were corrected for daily dose of clozapine (milligrams per kilogram of body weight). With valproic acid, there was a minor increase in total clozapine metabolites, which was even less with dose correction. Fluoxetine increased all clozapine analytes, in some cases to twice the levels in the subjects given only clozapine.

摘要

对单独使用氯氮平治疗的精神病患者（N = 17）、添加氟西汀的氯氮平治疗患者（N = 6）或添加丙戊酸的氯氮平治疗患者（N = 11）测定了血清中氯氮平、去甲氯氮平和氯氮平氮氧化物的浓度。受试者在年龄和其他治疗方面相匹配，并且浓度根据氯氮平的每日剂量（毫克/千克体重）进行了校正。使用丙戊酸时，氯氮平总代谢物略有增加，校正剂量后增加更少。氟西汀使所有氯氮平分析物增加，在某些情况下增加到仅给予氯氮平的受试者水平的两倍。