Bennett C L, Schrader A P, Morris B J
Department of Physiology, University of Sydney, N.S.W., Australia.
Biochem Biophys Res Commun. 1993 Dec 15;197(2):833-9. doi: 10.1006/bbrc.1993.2554.
A recent cross-sectional study of HTs in Salt Lake City and Paris has reported a significant association of a T704-->C (Met235-->Thr) variant in exon 2 of the angiotensinogen gene (AGT) with essential hypertension (HT). The present study used a new, direct PCR technique to detect this variant in 92 Caucasians with severe hypertension (HT) and two HT parents and 94 normotensive (NT) controls. Although frequency of the variant in HTs (0.42) was higher than in NTs (0.39), the difference was not significant (chi 2 = 0.24; P = 0.63). Plasma angiotensinogen showed a weak, nonsignificant relationship with AGT genotype in females and no genotypic relationship was apparent for blood pressure. Thus, if the Met235-->Thr variant of AGT is involved in essential HT, then its contribution may be, at best, much weaker in other HT groups.
最近一项针对盐湖城和巴黎高血压患者的横断面研究报告称，血管紧张素原基因（AGT）第2外显子中的T704→C（Met235→Thr）变体与原发性高血压（HT）存在显著关联。本研究采用一种新的直接PCR技术，在92名患有严重高血压且父母双方均患高血压的白种人以及94名血压正常（NT）的对照者中检测该变体。虽然高血压患者中该变体的频率（0.42）高于血压正常者（0.39），但差异不显著（卡方 = 0.24；P = 0.63）。血浆血管紧张素原在女性中与AGT基因型呈弱的、不显著的关系，且血压与基因型无明显关系。因此，如果AGT的Met235→Thr变体与原发性高血压有关，那么在其他高血压群体中，其作用充其量可能要弱得多。
