Ultrastructural changes in human leukemic cell nuclei.

The ultrastructural changes of human leukemic cell nuclei have been investigated. Particular attention is paid to the alteration of the nuclear envelope and its constituents, i.e., the pores and the Zonula Nucleum Limitans which appear constantly involved in these pathologic processes. An alteration of the relationship between the components of the nuclear envelope and the chromatin itself may be responsible for the appearance of the most nuclear changes.