Lee Y C, Taraschi T F, Janes N
Department of Pathology and Cell Biology, Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Biophys J. 1993 Oct;65(4):1429-32. doi: 10.1016/S0006-3495(93)81206-2.
Headgroup volumes of seven dioleoyl lipid species, calculated from covalent radii, are shown to correlate linearly (r = 0.95) with the ability of those lipids to alter the midpoint temperature of the lamellar to inverted hexagonal phase transition (L alpha-->HII) of a 95 mole fraction percent phosphatidylethanolamine matrix. The results illustrate the utility of the shape concept and basic considerations of headgroup volume as a predictive tool for the determination of lipid structure.
根据共价半径计算得出的七种二油酰脂质分子头部基团的体积,与这些脂质改变95摩尔分数百分比的磷脂酰乙醇胺基质从层状相向反六角相转变(Lα→HII)的中点温度的能力呈线性相关(r = 0.95)。结果表明了形状概念和头部基团体积的基本考量作为预测脂质结构的工具的实用性。