血清素能系统参与尼古丁对小鼠的活动减少和抗伤害感受作用。

Involvement of the serotonergic system in the hypoactive and antinociceptive effects of nicotine in mice.

作者信息

Damaj M I, Glennon R A, Martin B R

机构信息

Department of Pharmacology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0613.

出版信息

Brain Res Bull. 1994;33(2):199-203. doi: 10.1016/0361-9230(94)90252-6.

DOI:10.1016/0361-9230(94)90252-6

PMID:8275340

Abstract

Pretreatment with the 5-HT2 antagonist ketanserin and the 5-HT1A/2 antagonist spiperone did not reduce nicotine-induced hypomotility in mice, nor did MDL 7222, a selective 5-HT3 antagonist. In addition, 8-OH-DPAT and buspirone, 5-HT1A agonists, had no significant effects on nicotine-induced hypomotility. However, 8-OH-DPAT and buspirone did reduce the antinociceptive effects of nicotine in a dose-dependent manner. 8-OH-DPAT blockade of this nicotine effect was reversed by spiperone, a 5-HT1A/2 antagonist. Nicotine's ED50 was increased from 1.00 mg/kg (0.90-1.68) to 2.00 mg/kg (1.6-2.55) and 2.66 (1.7-3.51) by buspirone and 8-OH-DPAT, respectively. Ketanserin, spiperone and MDL 7222 had no significant effect on nicotine-induced antinociception. The present data suggest an important role of 5-HT1A receptors in the modulation of antinociceptive actions of nicotine.

摘要

用5-羟色胺2（5-HT2）拮抗剂酮色林和5-羟色胺1A/2（5-HT1A/2）拮抗剂螺哌隆进行预处理，并未降低尼古丁诱导的小鼠运动功能减退，选择性5-HT3拮抗剂MDL 7222也未降低。此外，5-HT1A激动剂8-羟基二丙胺四乙酸（8-OH-DPAT）和丁螺环酮对尼古丁诱导的运动功能减退无显著影响。然而，8-OH-DPAT和丁螺环酮确实以剂量依赖的方式降低了尼古丁的抗伤害感受作用。5-HT1A/2拮抗剂螺哌隆可逆转8-OH-DPAT对这种尼古丁效应的阻断作用。丁螺环酮和8-OH-DPAT分别使尼古丁的半数有效剂量（ED50）从1.00毫克/千克（0.90 - 1.68）增加到2.00毫克/千克（1.6 - 2.55）和2.66（1.7 - 3.51）。酮色林、螺哌隆和MDL 7222对尼古丁诱导的抗伤害感受无显著影响。目前的数据表明5-HT1A受体在调节尼古丁的抗伤害感受作用中起重要作用。