Fava M, Bless E, Otto M W, Pava J A, Rosenbaum J F
Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114.
J Nerv Ment Dis. 1994 Jan;182(1):45-9.
High levels of dysfunctional attitudes have been associated with greater severity of depression and poorer response to pharmacological treatment. The goal of our study was to examine this relationship and the changes in dysfunctional attitudes after treatment with fluoxetine, a relatively selective serotonin uptake inhibitor. Dysfunctional attitudes were evaluated with both the Cognitions Questionnaire (CQ) and the Dysfunctional Attitudes Scale (DAS) in 115 outpatients diagnosed as having major depressive disorder. After 8 weeks of treatment with fluoxetine, 67 of these patients again completed the DAS and the CQ. Dysfunctional attitudes were associated with depression severity both before and after treatment and decreased linearly with treatment of the depression. Negative thinking and dysfunctional attitudes, as measured by both DAS and CQ, were not predictive of the degree of improvement in depressive symptoms. These findings partly support a state-dependent interpretation of dysfunctional attitudes, and provide evidence of significant reductions in these attitudes after treatment with a serotonin uptake inhibitor.
功能失调性态度水平较高与抑郁症病情更严重以及药物治疗反应较差有关。我们研究的目的是检验这种关系以及使用相对选择性的5-羟色胺再摄取抑制剂氟西汀治疗后功能失调性态度的变化。采用认知问卷（CQ）和功能失调性态度量表（DAS）对115例被诊断为重度抑郁症的门诊患者的功能失调性态度进行评估。在用氟西汀治疗8周后，其中67例患者再次完成了DAS和CQ。功能失调性态度在治疗前后均与抑郁严重程度相关，并且随着抑郁症的治疗呈线性下降。用DAS和CQ测得的消极思维和功能失调性态度并不能预测抑郁症状的改善程度。这些发现部分支持了对功能失调性态度的状态依赖性解释，并提供了使用5-羟色胺再摄取抑制剂治疗后这些态度显著减少的证据。
