Moriwaka F, Tashiro K
Department of Neurology, Hokkaido University School of Medicine.
Nihon Rinsho. 1993 Nov;51(11):2952-6.
Sporadic olivopontocerebellar atrophy (OPCA), Shy-Drager syndrome (SDS), striatonigral degeneration (SND) are classified as multiple system atrophy (MSA), based on their clinicopathological findings. These clinical features, neuroimaging including CT, MRI, PET and SPECT findings, autonomic function test, pathological findings and treatments are reviewed. Several advances such as noradrenaline loading test, low signal intensity on T2 weighted image on super-conductive MRI and glial cytoplasmic inclusions in the central nervous system on pathological finding are notable. However, unsatisfactory medical treatment for MSA must be resolved in a near future.
散发性橄榄体脑桥小脑萎缩（OPCA）、Shy-Drager综合征（SDS）、纹状体黑质变性（SND）根据其临床病理表现被归类为多系统萎缩（MSA）。本文对这些疾病的临床特征、包括CT、MRI、PET和SPECT检查结果在内的神经影像学表现、自主神经功能测试、病理表现及治疗方法进行了综述。诸如去甲肾上腺素负荷试验、超导MRI的T2加权图像上的低信号强度以及病理检查时中枢神经系统中的胶质细胞胞质内包涵体等多项进展值得关注。然而，多系统萎缩令人不满意的医学治疗方法必须在不久的将来得到解决。
