Tice H, Barnes P D, Goumnerova L, Scott R M, Tarbell N J
Department of Radiology, Children's Hospital, Harvard Medical School, Boston, MA 02115.
AJNR Am J Neuroradiol. 1993 Nov-Dec;14(6):1293-300.
To review the clinical and imaging findings in pediatric and adolescent intracranial pure oligodendrogliomas.
The clinical, CT, and MR data in 39 surgically proved pure oligodendrogliomas were retrospectively reviewed.
The frontal or temporal lobes were involved in 32 (82%) cases. Seventy percent of the tumors were hypodense on CT, three-fourths were hypointense on T1-weighted images, and all were hyperintense on spin-density and T2-weighted images. Fewer than 40% of the lesions demonstrated calcification, and nearly 60% had well-defined margins. Mass effect was seen in fewer than half of the cases, and edema could be separately identified in only one case. Tumor enhancement was seen in fewer than 25%. In 39 cases after partial (3), subtotal (16), or total (20) resection, follow-up studies demonstrated stability over a mean period of 5 years.
The findings in this pediatric series of pure oligodendrogliomas (without mixed cell elements) differ from previous adult series in that calcification, contrast enhancement, and edema are seen less frequently. In addition, very slow or no growth is often characteristic, and these patients have an excellent prognosis with surgical resection.
回顾儿童和青少年颅内单纯性少突胶质细胞瘤的临床及影像学表现。
对39例经手术证实的单纯性少突胶质细胞瘤的临床、CT及MR数据进行回顾性分析。
32例（82%）肿瘤累及额叶或颞叶。70%的肿瘤在CT上呈低密度，四分之三在T1加权像上呈低信号，在自旋密度像和T2加权像上均呈高信号。不到40%的病灶有钙化，近60%边界清晰。不到一半的病例有占位效应，仅1例可单独识别出水肿。不到25%的病例有肿瘤强化。39例患者接受部分（3例）、次全（16例）或全切除（20例）后，随访研究显示平均5年病情稳定。
该儿童单纯性少突胶质细胞瘤（无混合细胞成分）系列的表现与以往成人系列不同，钙化、对比增强及水肿较少见。此外，生长非常缓慢或无生长常为其特点，手术切除后这些患者预后良好。
