在氟烷麻醉下，NG-硝基-L-精氨酸甲酯的脑血管效应得以保留。

Cerebrovascular effects of NG-nitro-L-arginine methylester are conserved under halothane anaesthesia.

作者信息

Dawson D A, McCulloch J, Macrae I M

机构信息

University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK.

出版信息

Eur J Pharmacol. 1993 Nov 2;249(1):7-11. doi: 10.1016/0014-2999(93)90655-2.

DOI:10.1016/0014-2999(93)90655-2

PMID:8282021

Abstract

The effects of the nitric oxide synthesis inhibitor NG-nitro-L-arginine methylester (L-NAME) on mean arterial blood pressure (MABP) and local cerebral blood flow were determined in conscious and halothane-anaesthetised rats. Thirty minutes post-drug administration in conscious rats L-NAME (30 mg kg-1 i.v.) induced significant hypertension (MABP 132 +/- 2 mmHg and 163 +/- 6 mmHg (means +/- S.D.) for saline and L-NAME groups respectively) and significant hypoperfusion throughout the brain (mean +/- S.D. reduction in cerebral blood flow 27.3 +/- 5.9% compared with controls). In contrast, under halothane anaesthesia, L-NAME did not significantly change MABP but significant reductions in cerebral blood flow (43.2 +/- 3.7%) were observed. Thus the cerebrovascular response to L-NAME is conserved under halothane anaesthesia despite attenuation of the peripheral vasoconstrictive action.

摘要

在清醒和氟烷麻醉的大鼠中，测定了一氧化氮合成抑制剂NG-硝基-L-精氨酸甲酯（L-NAME）对平均动脉血压（MABP）和局部脑血流量的影响。在清醒大鼠中，静脉注射L-NAME（30 mg kg-1）30分钟后，诱导出显著的高血压（生理盐水组和L-NAME组的MABP分别为132±2 mmHg和163±6 mmHg（均值±标准差）），并且全脑出现显著的灌注不足（与对照组相比，脑血流量平均±标准差减少27.3±5.9%）。相比之下，在氟烷麻醉下，L-NAME并未显著改变MABP，但观察到脑血流量显著减少（43.2±3.7%）。因此，尽管外周血管收缩作用减弱，但在氟烷麻醉下，脑血管对L-NAME的反应仍得以保留。