Sakono M, Yoshida K, Yahiro M
Sapporo Research Laboratory, Snow Brand Milk Products Co., Ltd., Sapporo, Japan.
J Nutr Sci Vitaminol (Tokyo). 1993 Aug;39(4):335-43. doi: 10.3177/jnsv.39.335.
The combined effects of dietary protein (casein, whey protein, or soy protein) and fat (safflower oil, perilla seed oil, or their mixed oil; linoleic acid/alpha-linolenic acid = 5.0) on several lipid parameters were studied in rats. Serum cholesterol and triglyceride levels were lower in perilla seed oil groups irrespective of the protein sources. Liver triglyceride level, and fecal excretion of steroids were influenced mainly by protein sources, particularly isolated soy protein lowered liver triglyceride level, and increased the fecal steroid excretion. The fatty acid composition of liver phosphatidylcholine was influenced by dietary fat sources. The proportion of arachidonic acid was significantly lower in rats fed perilla seed oil than in those fed safflower oil or mixed oil, while the proportion of eicosapentaenoic acid was higher in rats fed perilla seed oil than in those fed safflower oil. Arachidonic acid/linoleic acid ratio was significantly lower in perilla seed oil groups, and tended to be higher in casein groups. Eicosapentaenoic acid/arachidonic acid ratio was influenced by both dietary protein and fat, and protein-fat interaction was observed. Eicosapentaenoic acid/arachidonic acid ratio was higher in perilla seed oil groups, and isolated soy protein in perilla seed oil groups lowered the ratio in comparison with other protein sources in perilla seed oil groups.
研究了膳食蛋白质（酪蛋白、乳清蛋白或大豆蛋白）和脂肪（红花油、紫苏籽油或其混合油；亚油酸/α-亚麻酸 = 5.0）对大鼠几种脂质参数的联合作用。无论蛋白质来源如何，紫苏籽油组的血清胆固醇和甘油三酯水平均较低。肝脏甘油三酯水平和类固醇的粪便排泄主要受蛋白质来源的影响，特别是分离大豆蛋白降低了肝脏甘油三酯水平，并增加了粪便类固醇排泄。肝脏磷脂酰胆碱的脂肪酸组成受膳食脂肪来源的影响。饲喂紫苏籽油的大鼠中花生四烯酸的比例显著低于饲喂红花油或混合油的大鼠，而饲喂紫苏籽油的大鼠中二十碳五烯酸的比例高于饲喂红花油的大鼠。紫苏籽油组中花生四烯酸/亚油酸比值显著较低，酪蛋白组中该比值则有升高趋势。二十碳五烯酸/花生四烯酸比值受膳食蛋白质和脂肪两者的影响，且观察到蛋白质-脂肪相互作用。紫苏籽油组中二十碳五烯酸/花生四烯酸比值较高，紫苏籽油组中的分离大豆蛋白与紫苏籽油组中的其他蛋白质来源相比降低了该比值。
