大鼠肝脏微粒体混合功能氧化酶对膳食亚油酸水平的反应。

Response of liver microsomal mixed-function oxidases to dietary linoleic acid levels in rats.

作者信息

Saito M, Yamaguchi M

机构信息

Division of Food Science, National Institute of Health and Nutrition, Tokyo, Japan.

出版信息

J Nutr Sci Vitaminol (Tokyo). 1993 Aug;39(4):411-8. doi: 10.3177/jnsv.39.411.

DOI:10.3177/jnsv.39.411

PMID:8283320

Abstract

Responses of the activities of liver microsomal mixed-function oxidases (MFOs) induced by phenobarbital (PB) to dietary linoleic acid (LA) levels were investigated in rats. Diets varied in LA content (0, 1.8, 4.1, 7.0, or 13.8 energy%) were fed to rats for 16 days. The activities of MFOs did not change significantly with increasing the dietary LA level, where they reached a plateau even at 1.8 energy %, although the fatty acid composition of liver microsomal lipids reflected well that of dietary lipids. Accordingly, 2 energy % of LA as essential fatty acid seemed to be sufficient to supply the dietary requirement as assessed by the activities of PB-induced MFOs.

摘要

研究了苯巴比妥（PB）诱导的大鼠肝脏微粒体混合功能氧化酶（MFOs）活性对膳食亚油酸（LA）水平的反应。给大鼠喂食LA含量不同（0、1.8、4.1、7.0或13.8能量%）的饲料16天。尽管肝脏微粒体脂质的脂肪酸组成很好地反映了膳食脂质的脂肪酸组成，但随着膳食LA水平的增加，MFOs的活性没有显著变化，即使在1.8能量%时它们也达到了平台期。因此，以PB诱导的MFOs活性评估，2能量%的LA作为必需脂肪酸似乎足以满足膳食需求。