Cholelithiasis in homozygous sickle cell disease is a common complication. Mean prevalence rate recorded is 27.4% with a greater frequency in the second part of life. It is a peculiar lithiasis, made of pigmentary stones either purs or duals, caused by hypersaturation of indirect bilirubin. Systematic detection of such a lithiasis by echography is part of monitoring homozygous drepanocytic.