Hahn J A, Shaw G M
California Birth Defects Monitoring Program, Emeryville.
Paediatr Perinat Epidemiol. 1993 Oct;7(4):450-60. doi: 10.1111/j.1365-3016.1993.tb00426.x.
Trends in the prevalence of Down's syndrome in livebirths were examined in California from 1983 to 1988, a time period when prenatal screening and subsequent termination of Down's syndrome pregnancies among women under 35 years of age was increasing. In the population-based ascertainment areas of the California Birth Defects Monitoring Program (CBDMP), 1058 infants with Down's syndrome were identified, giving a crude prevalence of 1.03 (95% confidence interval [CI]: 0.97, 1.09). The risk ratio for 1988 compared with 1983, after adjusting for maternal age and other confounders, was 0.98 (95% CI: 0.78, 1.23), showing that there was no change in livebirth prevalence over this period. The data were also examined for mothers under 35 years of age to determine whether increasing use of prenatal screening leading to termination masked an increase in prevalence. A modest increase was seen.
1983年至1988年期间，在加利福尼亚州对活产婴儿中唐氏综合征的患病率趋势进行了研究，这一时期35岁以下女性的产前筛查以及随后对唐氏综合征妊娠的终止率都在上升。在加利福尼亚出生缺陷监测项目（CBDMP）基于人群的确定区域内，共识别出1058例唐氏综合征婴儿，粗患病率为1.03（95%置信区间[CI]：0.97，1.09）。在调整了产妇年龄和其他混杂因素后，1988年与1983年相比的风险比为0.98（95%CI：0.78，1.23），表明在此期间活产患病率没有变化。还对35岁以下的母亲的数据进行了检查，以确定产前筛查导致终止妊娠的使用增加是否掩盖了患病率的上升。结果发现有适度上升。
