Nottebohm E, Usui A, Therianos S, Kimura K, Dambly-Chaudière C, Ghysen A
Laboratory of Neurobiology, Université Libre de Bruxelles, Rhode-St-Genèse, Belgium.
Neuron. 1994 Jan;12(1):25-34. doi: 10.1016/0896-6273(94)90149-x.
The gene poxn codes for a transcriptional regulator that specifies poly-innervated (chemosensory), as opposed to mono-innervated (mechanosensory), organs in Drosophila. The ectopic expression of poxn during metamorphosis results in a transformation of the morphology and central projection of adult mechanosensory organs toward those of chemosensory organs. Here we show, by electron microscopy analysis of normal and transformed bristles and by Dil labeling of the innervating neurons, that poxn also controls the number of neurons. To determine whether poxn can transform not only the sense organ precursor cells but also their daughter cells, we examine the effects of the ectopic expression of poxn at different stages of the lineage, and we conclude that poxn can act at a late stage to affect the fate of the undifferentiated neuron.
基因poxn编码一种转录调节因子，它决定了果蝇中多神经支配（化学感受）的器官，而非单神经支配（机械感受）的器官。在变态过程中poxn的异位表达导致成年机械感受器官的形态和中枢投射向化学感受器官转变。在这里，我们通过对正常和转化刚毛的电子显微镜分析以及对支配神经元的Dil标记表明，poxn也控制神经元的数量。为了确定poxn是否不仅能转化感觉器官前体细胞，还能转化它们的子细胞，我们研究了在谱系不同阶段poxn异位表达的影响，并且得出结论，poxn可以在后期发挥作用来影响未分化神经元的命运。
