口服大剂量甲泼尼龙与静脉注射免疫球蛋白治疗儿童急性特发性血小板减少性紫癜的对比

Oral megadose methylprednisolone versus intravenous immunoglobulin for acute childhood idiopathic thrombocytopenic purpura.

作者信息

Ozsoylu S, Sayli T R, Oztürk G

机构信息

Department of Pediatric Hematology, University of Hacettepe, Medical Faculty, Ankara, Turkey.

出版信息

Pediatr Hematol Oncol. 1993 Oct-Dec;10(4):317-21. doi: 10.3109/08880019309029508.

DOI:10.3109/08880019309029508

PMID:8292515

Abstract

Twenty children with acute idiopathic thrombocytopenic purpura (ITP) were randomized to receive either oral megadose methylprednisolone (MDMP) or intravenous immunoglobulin G (IV IgG). Normal platelet counts (> or = 150 x 10(9)/l) were obtained in 6 patients of each group in 3 days and in 8 and 9 patients treated with oral MDMP and with IV IgG within 1 week, respectively. It is concluded that oral MDMP could easily be used for the early elevation of platelet counts, which is important for ITP treatment.

摘要

20名急性特发性血小板减少性紫癜（ITP）患儿被随机分组，分别接受口服大剂量甲基强的松龙（MDMP）或静脉注射免疫球蛋白G（IV IgG）治疗。每组各有6例患者在3天内血小板计数恢复正常（≥150×10⁹/L），接受口服MDMP和IV IgG治疗的患者分别有8例和9例在1周内血小板计数恢复正常。得出的结论是，口服MDMP可方便地用于早期提升血小板计数，这对ITP治疗很重要。