Scoto G M, Parenti C
Institute of Pharmacology and Pharmacognosy, Faculty of Pharmacy, University of Catania, Italy.
J Physiol Paris. 1993;87(6):385-8.
The effects of intraperitoneal and intracerebroventricular administration of mu- and delta- selective opioid receptor agonists (DAGO and DPDPE, respectively) on gastric lesions, were investigated in cold-restraint-stressed rats. DAGO and DPDPE, peripherally and centrally administered, induced a significant gastric protection. Naloxone prevented the effects of both opioids whereas naltrindole prevented the gastric protection induced by DPDPE but not that by DAGO. The results suggest that mu- and delta-opioid agonists prevent gastric damage induced by stress through an involvement of both central and peripheral mu- and delta-opioid receptor subtypes.
在冷束缚应激大鼠中，研究了腹腔注射和脑室内注射μ-和δ-选择性阿片受体激动剂（分别为DAGO和DPDPE）对胃损伤的影响。外周和中枢给予DAGO和DPDPE均诱导出显著的胃保护作用。纳洛酮可阻断两种阿片类药物的作用，而纳曲吲哚可阻断DPDPE诱导的胃保护作用，但不能阻断DAGO诱导的胃保护作用。结果表明，μ-和δ-阿片受体激动剂通过中枢和外周μ-和δ-阿片受体亚型的参与来预防应激诱导的胃损伤。
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