Otsuka M, Matsuda Y, Suwa Y, Fox J L, Higuchi W I
Kobe Women's College of Pharmacy, Japan.
Chem Pharm Bull (Tokyo). 1993 Nov;41(11):2055-7. doi: 10.1248/cpb.41.2055.
The resistance to crushing after a self-setting bioactive calcium phosphate cement, consisting of various particle sizes of tetracalcium phosphate (TECP), dicalcium phosphate dihydrate (DCPD) and hydroxyapatite (HAP), had hardened was tested after setting at 37 degrees C, 100% RH. X-ray diffraction suggested that the cement containing fine particles of DCPD and TECP was completely transformed to HAP, but that containing larger particles was not. Since particle size of both DCPD and TECP affected the dissolution rate, the crystal growth of HAP during cement formation depended on the specific surface area (Sw) of the raw materials. The crushing strength of the cement after hardening increased with an increase of its Sw.
一种由不同粒径的磷酸四钙（TECP）、二水磷酸二钙（DCPD）和羟基磷灰石（HAP）组成的自固化生物活性磷酸钙骨水泥在37℃、100%相对湿度下凝固后，对其硬化后的抗压强度进行了测试。X射线衍射表明，含有细颗粒DCPD和TECP的骨水泥完全转化为HAP，而含有较大颗粒的骨水泥则没有。由于DCPD和TECP的粒径均影响溶解速率，因此骨水泥形成过程中HAP的晶体生长取决于原材料的比表面积（Sw）。硬化后骨水泥的抗压强度随Sw的增加而提高。
