Lisanby S H, McDonald W M, Massey E W, Doraiswamy P M, Rozear M, Boyko O B, Krishnan K R, Nemeroff C
Department of Psychiatry, Duke University Medical Center, Durham, NC.
J Neural Transm Suppl. 1993;40:13-21.
Parkinson's disease (PD) is associated with changes in the substantia nigra, which communicates with subcortical nuclei. This study investigates subcortical nuclei volume in PD in vivo by magnetic resonance (MR) imaging. Caudate, putaminal, and thalamic nuclei were measured on axial MR images using a point counting method and systematic sampling. PD patients (n = 21) had significantly smaller subcortical nuclei than age- and sex-matched controls (p < 0.001) and depressed patients (p < 0.01). The decline in PD was not correlated with age, sex, or cortical volume. Depressed patients had significantly smaller caudate and putaminal nuclei than controls (p < 0.05 and 0.01, respectively) but thalamic nuclei were not significantly different. Caudate, putaminal, and thalamic nuclei volumes of controls were significantly negatively correlated with age (r = -0.58, p < 0.01; r = -0.77, p < 0.001; r = -0.57, p < 0.01, respectively). Depressed subjects demonstrated a negative trend. Volumetric measurements by MR imaging may be a useful in investigating the role of the basal ganglia in neurological disorders.
帕金森病（PD）与黑质的变化有关，黑质与皮质下核团相互联系。本研究通过磁共振（MR）成像在活体中研究帕金森病患者的皮质下核团体积。使用点计数法和系统抽样在轴向MR图像上测量尾状核、壳核和丘脑核团。帕金森病患者（n = 21）的皮质下核团明显小于年龄和性别匹配的对照组（p < 0.001）以及抑郁症患者（p < 0.01）。帕金森病患者核团体积的下降与年龄、性别或皮质体积无关。抑郁症患者的尾状核和壳核明显小于对照组（分别为p < 0.05和0.01），但丘脑核团无显著差异。对照组的尾状核、壳核和丘脑核团体积与年龄显著负相关（分别为r = -0.58，p < 0.01；r = -0.77，p < 0.001；r = -0.57，p < 0.01）。抑郁症患者呈现出负相关趋势。通过MR成像进行体积测量可能有助于研究基底神经节在神经疾病中的作用。
