Ichihara K, Abiko Y
Recent Adv Stud Cardiac Struct Metab. 1976;12:531-5.
Ligation of one of the small branches of the canine left anterior descending coronary artery produced a typical anaerobic response in the region of myocardium that had been perfused by the ligated artery; the myocardial glycogen and phosphocreatine levels decreased, and the myocardial phosphorylase activity increased after coronary artery ligation. Pretreatment of the dogs with nitroglycerin or propranolol prevented or diminished the typical anaerobic response of the myocardium to coronary artery ligation, but the pretreatment with dipyridamole did not.
结扎犬左冠状动脉前降支的一个小分支，会在由结扎动脉供血的心肌区域产生典型的无氧反应；冠状动脉结扎后，心肌糖原和磷酸肌酸水平降低，心肌磷酸化酶活性增加。用硝酸甘油或普萘洛尔对犬进行预处理可预防或减轻心肌对冠状动脉结扎的典型无氧反应，但双嘧达莫预处理则无此效果。
