J001X酰化聚半乳糖苷用于猪炎症性病变成像的闪烁成像潜力。

Scintigraphic potentials of J001X acylated poly-galactoside for imaging inflammatory lesions in pigs.

作者信息

Perin F, Pittet J C, Hoffschir D, Normier G, Binz H, Le Pape A

机构信息

Laboratoire de Biophysique Cellulaire et RMN, INSERM U316, Faculté de Médecine, Tours, France.

出版信息

Nucl Med Biol. 1993 Nov;20(8):963-71. doi: 10.1016/0969-8051(93)90097-e.

DOI:10.1016/0969-8051(93)90097-e

PMID:8298576

Abstract

Although several approaches already exist for the imaging of inflammatory foci, new specific strategies providing functional data on the lesions are required to determine the extent of the disease and also to assess anti-inflammatory treatment. In our study, we investigated the scintigraphic potential of 99mTc-J001X, an agent developed for the targeting of macrophages. Due to its well documented and progressive evolution of lesions, a model of radiation-induced inflammation in pigs was chosen. Our results demonstrated the ability of J001X to provide images of inflammatory foci with a high contrast. The contribution of some specific and non-specific parameters possibly involved in the scintigraphic behavior of J001X is discussed.

摘要

尽管目前已经存在几种用于炎症病灶成像的方法，但仍需要新的能够提供病灶功能数据的特异性策略，以确定疾病的范围并评估抗炎治疗效果。在我们的研究中，我们研究了99mTc-J001X的闪烁显像潜力，这是一种为靶向巨噬细胞而开发的试剂。由于猪辐射诱导炎症模型的病变有充分记录且病变进展过程清晰，所以选用了该模型。我们的结果表明J001X能够提供高对比度的炎症病灶图像。本文还讨论了一些可能与J001X闪烁显像行为有关的特异性和非特异性参数的作用。