Hashimoto H, Yamashiro M, Ootsubo K, Takahashi T, Kino K, Esaki Y
Department of Surgery, Tokyo Metropolitan Geriatric Hospital.
Nihon Ronen Igakkai Zasshi. 1993 Oct;30(10):879-84. doi: 10.3143/geriatrics.30.879.
Gastric ulcer was studied with regard to the relationship with patterns of distribution of intestinal metaplasia (IM). 882 stomachs of elderly patients, obtained from autopsies from 1987 to 1991 were examined histopathologically. There were 74 open gastric ulcers and 88 ulcer scars. Distribution of IM was classified into 7 types. Open ulcers and scars were found more often in type O (IM found in the entire lesser curvature which is the most common type in the elderly) than in other types. Open ulcers in type O were mostly shallow and located in the IM area. Many open ulcers in type A (IM involving the antrum) and type B (IM involving both the antrum and cardia) were deep and on the boundary zone between the IM area and the proper gastric mucosa area. Most of the deep scars that did occur in type O were in the IM area but in types B and A most of them were located on the boundary zone. Scars in type O probably developed on the boundary zone when they were open ulcers and removed in the IM area because of progression of the IM area. In some cases ulcers were at the boundary zone of IM involving the cardia and this finding was characteristic of elderly cases.
研究了胃溃疡与肠化生(IM)分布模式之间的关系。对1987年至1991年尸检获得的882例老年患者的胃进行了组织病理学检查。有74例开放性胃溃疡和88例溃疡瘢痕。IM的分布分为7种类型。与其他类型相比,O型(整个小弯侧均有IM,这是老年人中最常见的类型)中开放性溃疡和瘢痕更为常见。O型开放性溃疡大多较浅,位于IM区域。A型(胃窦部有IM)和B型(胃窦部和贲门部均有IM)的许多开放性溃疡较深,位于IM区域和胃固有黏膜区域之间的边界区。O型中确实出现的大多数深瘢痕位于IM区域,但B型和A型中的大多数深瘢痕位于边界区。O型瘢痕可能在开放性溃疡时在边界区形成,由于IM区域的进展而在IM区域消失。在某些情况下,溃疡位于涉及贲门的IM边界区,这一发现是老年病例的特征。