Mason K A, Tofilon P J
Department of Experimental Radiotherapy, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Cancer Chemother Pharmacol. 1994;33(5):435-7. doi: 10.1007/BF00686274.
A recent clinical protocol combining retinoic acid, interferon, and radiotherapy for advanced cervical cancer produced proctitis severe enough to necessitate dose reductions. In an attempt to model this biological response to multimodality therapy, we used a murine model to study the response of the colonic epithelium. Mice were treated with retinoic acid (100 micrograms/day) and interferon (3 x 10(4) units/day) for 5 days before undergoing whole-body irradiation. The functional response of the bowel was assessed by the ability to maintain body weight, and reproductive cell survival was quantified by the colon crypt assay. Both assays indicated a moderate protective effect of treatment with retinoic acid and interferon prior to irradiation. Protection factors in the range of 1.1-1.4 were observed.
最近一项针对晚期宫颈癌的联合使用维甲酸、干扰素和放疗的临床方案导致直肠炎严重到需要减少剂量。为了模拟这种对多模式治疗的生物学反应，我们使用小鼠模型来研究结肠上皮的反应。在进行全身照射前5天，用维甲酸（100微克/天）和干扰素（3×10⁴单位/天）对小鼠进行治疗。通过维持体重的能力评估肠道的功能反应，并通过结肠隐窝试验对生殖细胞存活进行定量。两种试验均表明，照射前用维甲酸和干扰素治疗具有中等程度的保护作用。观察到保护因子在1.1 - 1.4范围内。
