Starr R M
SmithKline Beecham Animal Health, West Chester, PA 19380.
Cornell Vet. 1993 Oct;83(4):311-23.
The safety profile of a new controlled-titer feline panleukopenia-rhinotracheitis-calicivirus-Chlamydia psittaci vaccine was compared to that of a currently-marketed vaccine. Of particular interest were delayed reactions (previously unreported in the literature in felines) occurring 7 to 21 days after vaccination, and the effect of concurrent vaccinations and cat age on the delayed reaction rate. Nineteen hundred twenty-four doses of the new vaccine and 364 doses of the comparison vaccine were administered in 42 participating veterinary practices. The postvaccination evaluation period was 21 days. Reactions (anaphylaxis, short- and long-term lethargy, inappetence, pain, upper respiratory inflammation, delayed fever, anorexia, and miscellaneous events) were reported in 3.33% of cats receiving the controlled-titer vaccine and in 3.02% of cats receiving the comparison vaccine. The difference was not statistically significant (P = 0.45). Reaction rate of the controlled-titer vaccine and that of the vaccine currently accepted by veterinarians appear to be equivalent.
将一种新型滴度可控的猫泛白细胞减少症-鼻气管炎-杯状病毒-鹦鹉热衣原体疫苗的安全性与一种目前市面上销售的疫苗进行了比较。特别令人感兴趣的是接种疫苗7至21天后出现的延迟反应（猫科动物文献中此前未报道过），以及同时接种疫苗和猫的年龄对延迟反应率的影响。在42家参与的兽医诊所中，共接种了1924剂新型疫苗和364剂对照疫苗。接种疫苗后的评估期为21天。接受滴度可控疫苗的猫中有3.33%出现了反应（过敏反应、短期和长期嗜睡、食欲不振、疼痛、上呼吸道炎症、延迟发热、厌食和其他事件），接受对照疫苗的猫中有3.02%出现了反应。差异无统计学意义（P = 0.45）。滴度可控疫苗的反应率与目前兽医认可的疫苗的反应率似乎相当。
