γ射线辐照碳水化合物对离体突触膜的影响。

Effect of gamma-irradiated carbohydrates on isolated synaptic membranes.

作者信息

Kaler G V, Lyskova T I, Shadyro O I, Samoilenko S G, Edimecheva I P, Aksentsev S L, Konev S V

机构信息

Institute of Photobiology, Academy of Sciences of Belarus, Minsk.

出版信息

Radiat Environ Biophys. 1993;32(4):345-55. doi: 10.1007/BF01225922.

DOI:10.1007/BF01225922

PMID:8310129

Abstract

The effect of gamma-irradiated solutions of carbohydrates, mainly glucose, upon Na+, K(+)-ATPase and lipid peroxidation in rat brain synaptosomal membranes was studied. The membrane damage by irradiated glucose was enhanced in the presence of Fe2+ and was diminished when a free-radical scavenger (BHT) or metal chelators (EDTA, EGTA) were present. It is suggested that a key element in the free-radical membrane damage by irradiated carbohydrates is an Fe(2+)-complex of some species of the radiolysis products. Participation of radiotoxins of carbohydrate origin in radiobiological effects is discussed.

摘要

研究了经γ射线辐照的碳水化合物溶液（主要是葡萄糖）对大鼠脑突触体膜中Na +、K(+)-ATP酶和脂质过氧化的影响。在Fe2+存在的情况下，辐照葡萄糖对膜的损伤增强；而当存在自由基清除剂（丁基羟基甲苯）或金属螯合剂（乙二胺四乙酸、乙二醇双乙醚二胺四乙酸）时，损伤则减轻。有人提出，碳水化合物辐照引起的自由基膜损伤中的关键因素是某些辐射分解产物的Fe(2+)络合物。文中还讨论了碳水化合物来源的辐射毒素在放射生物学效应中的作用。