Ebrahim Z Y, Schubert A, Van Ness P, Wolgamuth B, Awad I
Department of General Anesthesiology, Cleveland Clinic Foundation, Ohio 44195.
Anesth Analg. 1994 Feb;78(2):275-9. doi: 10.1213/00000539-199402000-00013.
The effect of propofol on the electroencephalogram (EEG) in patients with epilepsy is still unclear. Case reports with electroencephalographic documentation highlight pro- and anticonvulsant effects and beta activation of the EEG. This prospective study sought to determine the effect of propofol in 17 patients undergoing cortical resection for intractable epilepsy. Each patient received 2 mg/kg of propofol intravenously and the EEG was recorded from chronically implanted subdural electrodes placed during a previous craniotomy. Frequency of interictal spikes, time to burst suppression, and appearance of beta activation were recorded. The median frequency of interictal spikes decreased significantly from 2 spikes/min before to 0 spikes/min after propofol (P = 0.001). Seizure activity did not increase after propofol. Profound burst suppression and an increase in beta activity were noted consistently. The use of propofol in patients with epilepsy seems to be safe but may interfere with the recording of EEG spikes.
丙泊酚对癫痫患者脑电图（EEG）的影响仍不明确。有脑电图记录的病例报告突出了其惊厥前和抗惊厥作用以及脑电图的β波激活。这项前瞻性研究旨在确定丙泊酚对17例因顽固性癫痫接受皮质切除术患者的影响。每位患者静脉注射2mg/kg丙泊酚，并通过先前开颅手术期间植入的慢性硬膜下电极记录脑电图。记录发作间期棘波频率、爆发抑制时间和β波激活的出现情况。发作间期棘波的中位频率从丙泊酚注射前的2次/分钟显著降至注射后的0次/分钟（P = 0.001）。丙泊酚注射后癫痫活动未增加。持续观察到深度爆发抑制和β波活动增加。丙泊酚在癫痫患者中的使用似乎是安全的，但可能会干扰脑电图棘波的记录。
