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马立克氏病：B 组织相容性等位基因在抗性和易感鸡品系中的作用

Marek's disease: effects of B histocompatibility alloalleles in resistant and susceptible chicken lines.

作者信息

Briles W E, Stone H A, Cole R K

出版信息

Science. 1977 Jan 14;195(4274):193-5. doi: 10.1126/science.831269.

DOI:10.1126/science.831269
PMID:831269
Abstract

Lines of chickens selected from a common ancestral population for either resistance or susceptibility to Marek's disease developed contrasting frequencies of particular B alloalleles. Comparison of inoculated sibs in backcross-families revealed that the B alloalleles characterizing the two lines accounted for an eightfold difference in tumor incidence. This genetic difference in tumorigenesis associated with the alloalleles of the major histocompatibility complex is probably expressed through the cell-mediated immune system.

摘要

从共同祖先群体中选择出的对马立克氏病具有抗性或易感性的鸡品系，特定B等位基因的频率出现了明显差异。对回交家系中接种后的同胞进行比较发现，这两个品系所特有的B等位基因在肿瘤发生率上造成了八倍的差异。这种与主要组织相容性复合体的等位基因相关的肿瘤发生遗传差异，可能是通过细胞介导的免疫系统来表达的。

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Marek's disease: effects of B histocompatibility alloalleles in resistant and susceptible chicken lines.马立克氏病：B 组织相容性等位基因在抗性和易感鸡品系中的作用
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Development and characterization of a Marek's disease transplantable tumor in inbred line 72 chickens homozygous at the major (B) histocompatibility locus.在主要（B）组织相容性位点纯合的近交系72鸡中开发和鉴定马立克氏病可移植肿瘤。
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Studies of histocompatibility and immune response of chickens selected for resistance and susceptibility to Marek's disease.针对对马立克氏病具有抗性和易感性的鸡进行组织相容性和免疫反应的研究。
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Adv Exp Med Biol. 1977;88:287-98. doi: 10.1007/978-1-4613-4169-7_27.

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