Offstad J, Kirkebøen K A, Lande K, Ilebekk A
Institute for Experimental Medical Research, University of Oslo, Ullevål Hospital, Norway.
Cardiovasc Res. 1993 Dec;27(12):2248-53. doi: 10.1093/cvr/27.12.2248.
The aim was to determine the cardiac consequences of a 1 h period of mild regional low flow ischaemia in the pig heart.
In eight pentobarbitone sodium anaesthetised pigs (weight range 23-38 kg), the mid left anterior descending coronary artery was constricted by a hydraulic occluder. Transmural coronary blood flow (Doppler flowmetry) was reduced to approximately 70% of control for 1 h. After complete release of the occluder cardiac function was monitored for 2 h. Left ventricular segment lengths were continuously recorded in the region subjected to low flow ischaemia and in a control region supplied by the circumflex artery.
After 1 h with a 28(SEM 3)% reduction in coronary blood flow, the systolic shortening index decreased from 100 to 68(7) (p < 0.001). This index transiently normalised upon reperfusion. Thereafter it declined, reaching a nadir of 72(5) at 1.25 h of reperfusion, and subsequently improved to 82(6) at 2 h of reperfusion.
Normalisation of local myocardial function appears during the first minutes of reperfusion after 1 h of mild low flow ischaemia and is followed by a period of stunning.
旨在确定猪心脏轻度区域性低流量缺血1小时的心脏后果。
对8只戊巴比妥钠麻醉的猪（体重范围23 - 38千克），用液压闭塞器压迫左冠状动脉前降支中段。经壁冠状动脉血流（多普勒血流测定法）减少至对照值的约70%，持续1小时。完全解除闭塞器后，监测心脏功能2小时。连续记录低流量缺血区域及由回旋支动脉供血的对照区域的左心室节段长度。
冠状动脉血流减少28（标准误3）%持续1小时后，收缩期缩短指数从100降至68（7）（p < 0.001）。该指数在再灌注时短暂恢复正常。此后下降，在再灌注1.25小时时降至最低点72（5），随后在再灌注2小时时改善至82（6）。
轻度低流量缺血1小时后，局部心肌功能在再灌注的最初几分钟内出现恢复正常，随后是一段心肌顿抑期。
