热量限制能显著抑制雄性小鼠在被6-硝基 Chrysene 引发后肝脏肿瘤的形成。

Caloric restriction profoundly inhibits liver tumor formation after initiation by 6-nitrochrysene in male mice.

作者信息

Fu P P, Dooley K L, Von Tungeln L S, Bucci T, Hart R W, Kadlubar F F

机构信息

National Center for Toxicological Research, Jefferson, AR 72079.

出版信息

Carcinogenesis. 1994 Feb;15(2):159-61. doi: 10.1093/carcin/15.2.159.

DOI:10.1093/carcin/15.2.159

PMID:8313502

Abstract

Caloric restriction (CR) inhibited strongly the incidence of chemically-induced tumors in the neonatal B6C3F1 mouse tumorigenicity bioassay, when begun 3 months after treatment with the potent carcinogen 6-nitrochrysene. These data indicate that CR can have a profound inhibitory effect on tumor development even long after metabolic activation and DNA repair have occurred.

摘要

在新生B6C3F1小鼠致癌性生物测定中，在用强效致癌物6-硝基chrysene治疗3个月后开始热量限制（CR），可强烈抑制化学诱导肿瘤的发生率。这些数据表明，即使在代谢活化和DNA修复发生很长时间后，热量限制对肿瘤发展仍可产生深远的抑制作用。